Protein annotation from protein interaction networks and Gene Ontology.
Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen CD
PROVIDER: S-EPMC3176917 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Protein annotation from protein interaction networks and Gene Ontology.
Nguyen Cao D CD Gardiner Katheleen J KJ Cios Krzysztof J KJ
Journal of biomedical informatics 20110506 5
We introduce a novel method for annotating protein function that combines Naïve Bayes and association rules, and takes advantage of the underlying topology in protein interaction networks and the structure of graphs in the Gene Ontology. We apply our method to proteins from the Human Protein Reference Database (HPRD) and show that, in comparison with other approaches, it predicts protein functions with significantly higher recall with no loss of precision. Specifically, it achieves 51% precision ...[more]
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