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Clinical and genetic correlates of severity in schizophrenia in India: an ordinal logistic regression approach.

ABSTRACT: Genetic association studies of schizophrenia typically utilize diagnostic status as the trait of interest. Among Indian schizophrenia (SZ) participants, we evaluated genetic associations (selected single nucleotide polymorphisms (SNPs) associated with SZ) with selected indices of severity and symptom pattern. Ordinal logistic regression enabled us to analyze variables with multiple categories as outcome variables, while incorporating key demographic variables; this form of analysis may be useful in future genetic association studies. No significant associations were detected following corrections for multiple comparisons.

SUBMITTER: Thomas P 

PROVIDER: S-EPMC3177002 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Clinical and genetic correlates of severity in schizophrenia in India: an ordinal logistic regression approach.

Thomas Pramod P   Chandra Abha A   Bhatia Triptish T   Mishra N N NN   Sharma Vikash Ranjan VR   Gauba Deepak D   Wood Joel J   Chowdari Kodavali K   Semwal Prachi P   Thelma B K BK   Nimgaonkar Vishwajit L VL   Deshpande Smita N SN  

Psychiatry research 20110528 2

Genetic association studies of schizophrenia typically utilize diagnostic status as the trait of interest. Among Indian schizophrenia (SZ) participants, we evaluated genetic associations (selected single nucleotide polymorphisms (SNPs) associated with SZ) with selected indices of severity and symptom pattern. Ordinal logistic regression enabled us to analyze variables with multiple categories as outcome variables, while incorporating key demographic variables; this form of analysis may be useful  ...[more]

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