Ontology highlight
ABSTRACT:
SUBMITTER: Volinsky R
PROVIDER: S-EPMC3177064 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Volinsky Roman R Cwiklik Lukasz L Jurkiewicz Piotr P Hof Martin M Jungwirth Pavel P Kinnunen Paavo K J PK
Biophysical journal 20110920 6
Lipid asymmetry is a ubiquitous property of the lipid bilayers in cellular membranes and its maintenance and loss play important roles in cell physiology, such as blood coagulation and apoptosis. The resulting exposure of phosphatidylserine on the outer surface of the plasma membrane has been suggested to be caused by a specific membrane enzyme, scramblase, which catalyzes phospholipid flip-flop. Despite extensive research the role of scramblase(s) in apoptosis has remained elusive. Here, we sho ...[more]