Ontology highlight
ABSTRACT:
SUBMITTER: Modali SD
PROVIDER: S-EPMC3177148 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Modali Sita D SD Zgurskaya Helen I HI
Molecular microbiology 20110704 4
Escherichia coli MacAB-TolC is a tripartite macrolide efflux transporter driven by hydrolysis of ATP. In this complex, MacA is the periplasmic membrane fusion protein that stimulates the activity of MacB transporter and establishes the link with the outer membrane channel TolC. The molecular mechanism by which MacA stimulates MacB remains unknown. Here, we report that the periplasmic membrane proximal domain of MacA plays a critical role in functional MacA-MacB interactions and stimulation of Ma ...[more]