Ontology highlight
ABSTRACT:
SUBMITTER: Stagno JR
PROVIDER: S-EPMC3177189 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Stagno Jason R JR Altieri Amanda S AS Bubunenko Mikhail M Tarasov Sergey G SG Li Jess J Court Donald L DL Byrd R Andrew RA Ji Xinhua X
Nucleic acids research 20110607 17
Processive transcription antitermination requires the assembly of the complete antitermination complex, which is initiated by the formation of the ternary NusB-NusE-BoxA RNA complex. We have elucidated the crystal structure of this complex, demonstrating that the BoxA RNA is composed of 8 nt that are recognized by the NusB-NusE heterodimer. Functional biologic and biophysical data support the structural observations and establish the relative significance of key protein-protein and protein-RNA i ...[more]