Ontology highlight
ABSTRACT:
SUBMITTER: Russo A
PROVIDER: S-EPMC3177206 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Russo Annapina A Catillo Morena M Esposito Davide D Briata Paola P Pietropaolo Concetta C Russo Giulia G
Nucleic acids research 20110625 17
Alternative pre-mRNA splicing (AS) is a major mechanism that allows proteomic variability in eukaryotic cells. However, many AS events result in mRNAs containing a premature termination codon, which are degraded by nonsense-mediated mRNA decay (NMD) pathway. We have previously demonstrated that human rpL3 autoregulates its expression through the association of AS with NMD. In fact, overexpression of rpL3 promotes downregulation of canonical splicing and upregulation of alternative splicing that ...[more]