Ontology highlight
ABSTRACT:
SUBMITTER: Park SM
PROVIDER: S-EPMC3177222 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Park Sung Mi SM Paek Ki Young KY Hong Ka Young KY Jang Christopher J CJ Cho Sungchan S Park Ji Hoon JH Kim Jong Heon JH Jan Eric E Jang Sung Key SK
Nucleic acids research 20110628 17
Translation of many cellular and viral mRNAs is directed by internal ribosomal entry sites (IRESs). Several proteins that enhance IRES activity through interactions with IRES elements have been discovered. However, the molecular basis for the IRES-activating function of the IRES-binding proteins remains unknown. Here, we report that NS1-associated protein 1 (NSAP1), which augments several cellular and viral IRES activities, enhances hepatitis C viral (HCV) IRES function by facilitating the forma ...[more]