Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC3177653 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Liu Zhaohui Z Hamamichi Shusei S Lee Byoung Dae BD Yang Dejun D Ray Arpita A Caldwell Guy A GA Caldwell Kim A KA Dawson Ted M TM Smith Wanli W WW Dawson Valina L VL
Human molecular genetics 20110718 20
Mutations in leucine-rich repeat kinase 2 (LRRK2) have been identified as a genetic cause of familial Parkinson's disease (PD) and have also been found in the more common sporadic form of PD, thus positioning LRRK2 as important in the pathogenesis of PD. Biochemical studies of the disease-causing mutants of LRRK2 implicates an enhancement of kinase activity as the basis of neuronal toxicity and thus possibly the pathogenesis of PD due to LRRK2 mutations. Previously, a chemical library screen ide ...[more]