Ontology highlight
ABSTRACT:
SUBMITTER: Bradley DT
PROVIDER: S-EPMC3178140 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Bradley D T DT Zipfel P F PF Hughes A E AE
Eye (London, England) 20110311 6
Age-related macular degeneration (AMD) is an inflammatory disease, which causes visual impairment and blindness in older people. The proteins of the complement system are central to the development of this disease. Local and systemic inflammation in AMD are mediated by the deregulated action of the alternative pathway of the complement system. Variants in complement system genes alter an individual's risk of developing AMD. Recent studies have shown how some risk-associated genetic variants alte ...[more]