Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood.
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ABSTRACT:
SUBMITTER: Hanley PJ
PROVIDER: S-EPMC3178185 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
Improving clinical outcomes using adoptively transferred immune cells from umbilical cord blood.
Hanley Patrick J PJ Cruz Conrad Russell CR Shpall Elizabeth J EJ Bollard Catherine M CM
Cytotherapy 20101001 6
Because of the necessary immunodepletion prior to cord blood transplantation as well as the immaturity of cord blood immune cells, recipients experience a high incidence of viral infection in addition to complications observed after hematopoietic stem cell transplantation, such as relapse and graft-versus-host disease. We describe current immunotherapeutic approaches to treating these complications, including the generation of antigen-specific T cells from cord blood, redirecting cord blood T ce ...[more]
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