Ontology highlight
ABSTRACT:
SUBMITTER: Lundgaard GL
PROVIDER: S-EPMC3178729 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Lundgaard Greta L GL Daniels Natae E NE Pyndiah Slovénie S Cassimere Erica K EK Ahmed Kazi M KM Rodrigue Amélie A Kihara Daisuke D Post Carol B CB Sakamuro Daitoku D
Journal of cellular biochemistry 20111001 10
Bridging integrator 1 (BIN1) is a nucleocytoplasmic adaptor protein with tumor suppressor properties. The protein interacts with and inhibits the c-MYC transcription factor through the BIN1 MYC-binding domain (MBD). However, in vitro colony formation assays have clearly demonstrated that the MBD is not essential for BIN1-mediated growth arrest. We hypothesized that BIN1 contains a MYC-independent effector domain (MID) for cancer suppression. Because a functionally unique domain frequently contai ...[more]