Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC3178889 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Zhang Houbin H Constantine Ryan R Vorobiev Sergey S Chen Yang Y Seetharaman Jayaraman J Huang Yuanpeng Janet YJ Xiao Rong R Montelione Gaetano T GT Gerstner Cecilia D CD Davis M Wayne MW Inana George G Whitby Frank G FG Jorgensen Erik M EM Hill Christopher P CP Tong Liang L Baehr Wolfgang W
Nature neuroscience 20110605 7
UNC119 is widely expressed among vertebrates and other phyla. We found that UNC119 recognized the acylated N terminus of the rod photoreceptor transducin α (Tα) subunit and Caenorhabditis elegans G proteins ODR-3 and GPA-13. The crystal structure of human UNC119 at 1.95-Å resolution revealed an immunoglobulin-like β-sandwich fold. Pulldowns and isothermal titration calorimetry revealed a tight interaction between UNC119 and acylated Gα peptides. The structure of co-crystals of UNC119 with an acy ...[more]