Ontology highlight
ABSTRACT:
SUBMITTER: Clasadonte J
PROVIDER: S-EPMC3179065 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Clasadonte Jerome J Poulain Pierre P Hanchate Naresh K NK Corfas Gabriel G Ojeda Sergio R SR Prevot Vincent V
Proceedings of the National Academy of Sciences of the United States of America 20110906 38
Astrocytes in the hypothalamus release prostaglandin E(2) (PGE(2)) in response to cell-cell signaling initiated by neurons and glial cells. Upon release, PGE(2) stimulates the secretion of gonadotropin-releasing hormone (GnRH), the neuropeptide that controls reproduction, from hypothalamic neuroendocrine neurons. Whether this effect on GnRH secretion is accompanied by changes in the firing behavior of these neurons is unknown. Using patch-clamp recording we demonstrate that PGE(2) exerts a dose- ...[more]