Neural-specific elongation of 3' UTRs during Drosophila development.
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ABSTRACT:
SUBMITTER: Hilgers V
PROVIDER: S-EPMC3179109 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Neural-specific elongation of 3' UTRs during Drosophila development.
Hilgers Valérie V Perry Michael W MW Hendrix David D Stark Alexander A Levine Michael M Haley Benjamin B
Proceedings of the National Academy of Sciences of the United States of America 20110906 38
The 3' termini of eukaryotic mRNAs influence transcript stability, translation efficiency, and subcellular localization. Here we report that a subset of developmental regulatory genes, enriched in critical RNA-processing factors, exhibits synchronous lengthening of their 3' UTRs during embryogenesis. The resulting UTRs are up to 20-fold longer than those found on typical Drosophila mRNAs. The large mRNAs emerge shortly after the onset of zygotic transcription, with several of these genes acquiri ...[more]
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