Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC3179348 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lu Yongbo Y Yuan Baozhi B Qin Chunlin C Cao Zhengguo Z Xie Yixia Y Dallas Sarah L SL McKee Marc D MD Drezner Marc K MK Bonewald Lynda F LF Feng Jian Q JQ
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20110201 2
Dentin matrix protein 1 (DMP-1) is a key molecule in controlling osteocyte formation and phosphate homeostasis. Based on observations that full-length DMP-1 is not found in bone, but only cleaved fragments of 37 and 57 kDa are present, and in view of the finding that mutations in the 57-kDa fragment result in disease, we hypothesized that the 57-kDa C-terminal fragment is the functional domain of DMP-1. To test this hypothesis, a 3.6-kb type I collagen promoter was used to express this 57-kDa C- ...[more]