Ontology highlight
ABSTRACT:
SUBMITTER: Hodge JN
PROVIDER: S-EPMC3179394 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hodge Jessica N JN Srinivasula Sharat S Hu Zonghui Z Read Sarah W SW Porter Brian O BO Kim Insook I Mican Joann M JM Paik Chang C Degrange Paula P Di Mascio Michele M Sereti Irini I
Blood 20110721 12
IL-7 is essential for T-cell homeostasis. Elevated serum IL-7 levels in lymphopenic states, including HIV infection, are thought to be due to increased production by homeostatic feedback, decreased receptor-mediated clearance, or both. The goal of this study was to understand how immune reconstitution through antiretroviral therapy (ART) in HIV(+) patients affects IL-7 serum levels, expression of the IL-7 receptor (CD127), and T-cell cycling. Immunophenotypic analysis of T cells from 29 HIV(-) c ...[more]