Ontology highlight
ABSTRACT:
SUBMITTER: Arab K
PROVIDER: S-EPMC3179423 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Arab Khelifa K Smith Laura T LT Gast Andreas A Weichenhan Dieter D Huang Joseph Po-Hsien JP Claus Rainer R Hielscher Thomas T Espinosa Allan V AV Ringel Matthew D MD Morrison Carl D CD Schadendorf Dirk D Kumar Rajiv R Plass Christoph C
Carcinogenesis 20110718 10
Metastatic melanoma is a fatal disease due to the lack of successful therapies and biomarkers for early detection and its incidence has been increasing. Genetic studies have defined recurrent chromosomal aberrations, suggesting the location of either tumor suppressor genes or oncogenes. Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported functions in early lung and kidney development as well as tumor suppressor function in the malignancies of ...[more]