Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.
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ABSTRACT:
SUBMITTER: Chauhan G
PROVIDER: S-EPMC3179901 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
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Common variants of homocysteine metabolism pathway genes and risk of type 2 diabetes and related traits in Indians.
Chauhan Ganesh G Kaur Ismeet I Tabassum Rubina R Dwivedi Om Prakash OP Ghosh Saurabh S Tandon Nikhil N Bharadwaj Dwaipayan D
Experimental diabetes research 20110925
Hyperhomocysteinemia, a risk factor for cardiovascular disorder, obesity, and type 2 diabetes, is prevalent among Indians who are at high risk of these metabolic disorders. We evaluated association of common variants of genes involved in homocysteine metabolism or its levels with type 2 diabetes, obesity, and related traits in North Indians. We genotyped 90 variants in initial phase (2.115 subjects) and replicated top signals in an independent sample set (2.085 subjects). The variant MTHFR-rs180 ...[more]
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