Ontology highlight
ABSTRACT:
SUBMITTER: Nagano Y
PROVIDER: S-EPMC3180198 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Nagano Yoshito Y Fukushima Toru T Okemoto Kazuo K Tanaka Keiichiro K Bowtell David D L DD Ronai Ze'ev Z Reed John C JC Matsuzawa Shu-ichi S
Cell cycle (Georgetown, Tex.) 20110801 15
p27(kip1) has been implicated in cell cycle regulation, functioning as an inhibitor of cyclin-dependent kinase activity. In addition, p27 was also shown to affect cell migration, with accumulation of cytoplasmic p27 associated with tumor invasiveness. However, the mechanism underlying p27 regulation as a cytoplasmic protein is poorly understood. Here we show that glucose starvation induces proteasome-dependent degradation of cytoplasmic p27, accompanied by a decrease in cell motility. We also sh ...[more]