Ontology highlight
ABSTRACT:
SUBMITTER: Elis S
PROVIDER: S-EPMC3180229 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Elis Sebastien S Wu Yingjie Y Courtland Hayden-William HW Cannata Dara D Sun Hui H Beth-On Mordechay M Liu Chengyu C Jasper Hector H Domené Horacio H Karabatas Liliana L Guida Clara C Basta-Pljakic Jelena J Cardoso Luis L Rosen Clifford J CJ Frystyk Jan J Yakar Shoshana S
Disease models & mechanisms 20110531 5
Understanding insulin-like growth factor-1 (IGF1) biology is of particular importance because, apart from its role in mediating growth, it plays key roles in cellular transformation, organ regeneration, immune function, development of the musculoskeletal system and aging. IGF1 bioactivity is modulated by its binding to IGF-binding proteins (IGFBPs) and the acid labile subunit (ALS), which are present in serum and tissues. To determine whether IGF1 binding to IGFBPs is necessary to facilitate nor ...[more]