Comparing bivalent and quadrivalent human papillomavirus vaccines: economic evaluation based on transmission model.

ABSTRACT:

Objectives

To compare the effect and cost effectiveness of bivalent and quadrivalent human papillomavirus (HPV) vaccination, taking into account differences in licensure indications, protection against non-vaccine type disease, protection against disease related to HPV types 6 and 11, and reported long term immunogenicity.

Design

A model of HPV transmission and disease previously used to inform UK vaccination policy, updated with recent evidence and expanded to include scenarios where the two vaccines differ in duration of protection, cross protection, and end points prevented.

Setting

United Kingdom. Population Males and females aged 12-75 years.

Main outcome measure

Incremental cost effectiveness ratios for both vaccines and additional cost per dose for the q

SUBMITTER: Jit M 

PROVIDER: S-EPMC3181234 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature