Dataset Information

Intravascular food reward.

ABSTRACT: Consumption of calorie-containing sugars elicits appetitive behavioral responses and dopamine release in the ventral striatum, even in the absence of sweet-taste transduction machinery. However, it is unclear if such reward-related postingestive effects reflect preabsorptive or postabsorptive events. In support of the importance of postabsorptive glucose detection, we found that, in rat behavioral tests, high concentration glucose solutions administered in the jugular vein were sufficient to condition a side-bias. Additionally, a lower concentration glucose solution conditioned robust behavioral responses when administered in the hepatic-portal, but not the jugular vein. Furthermore, enteric administration of glucose at a concentration that is sufficient to elicit behavioral conditioning resulted in a glycemic profile similar to that observed after administration of the low concentration glucose solution in the hepatic-portal, but not jugular vein. Finally using fast-scan cyclic voltammetry we found that, in accordance with behavioral findings, a low concentration glucose solution caused an increase in spontaneous dopamine release events in the nucleus accumbens shell when administered in the hepatic-portal, but not the jugular vein. These findings demonstrate that the postabsorptive effects of glucose are sufficient for the postingestive behavioral and dopaminergic reward-related responses that result from sugar consumption. Furthermore, glycemia levels in the hepatic-portal venous system contribute more significantly for this effect than systemic glycemia, arguing for the participation of an intra-abdominal visceral sensor for glucose.

SUBMITTER: Oliveira-Maia AJ

PROVIDER: S-EPMC3181252 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Intravascular food reward.

Oliveira-Maia Albino J AJ Roberts Craig D CD Walker Q David QD Luo Brooke B Kuhn Cynthia C Simon Sidney A SA Nicolelis Miguel A L MA

PloS one 20110927 9

Consumption of calorie-containing sugars elicits appetitive behavioral responses and dopamine release in the ventral striatum, even in the absence of sweet-taste transduction machinery. However, it is unclear if such reward-related postingestive effects reflect preabsorptive or postabsorptive events. In support of the importance of postabsorptive glucose detection, we found that, in rat behavioral tests, high concentration glucose solutions administered in the jugular vein were sufficient to con ...[more]

PMID: 21980372

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Project description:Food reward is an important concept for research in eating behaviors. Many food reward tasks have been developed and are in active use. However, little is known how much these tasks overlap. Here, we sought to compare three promising food reward tasks: (1) the Leeds Food Preference Questionnaire (LFPQ; a procedure combining explicit ratings of wanting and liking and an implicit wanting task based on forced choice), (2) a hand grip force task, and (3) an emotional attentional blink (EAB) task. Specifically, we assessed whether the tasks are sensitive to changes in hunger, correlate with each other, and correlate with trait binge eating and snack food calorie intake. Thirty-nine women aged 25.51 ± 5.99 years, with a BMI of 22.51 ± 3.58 kg/m2 completed the three tasks twice: after a 6-h fast and following a breakfast meal. In the fasted condition, participants were also given ad libitum access to snack foods to assess calorie intake. Prior to the two laboratory sessions, participants completed a trait binge eating questionnaire. Results revealed that the LFPQ's explicit wanting and explicit liking subscales, as well as grip force reflected higher food reward scores in the fasted condition. The three metrics also correlated positively with each other. Explicit wanting and liking correlated with snack food intake, while grip force did not. None of the tasks were related to trait binge eating. Reaction times in the forced choice procedure did not reflect changes in hunger, but the task was nevertheless able to differentiate between foods varying in taste and fat content. The EAB was not sensitive to the hunger manipulation; neither did the task correlate with binge eating or energy intake. Collectively, our findings suggest that the explicit wanting and liking scales and the grip force task measure the same construct, whereas EAB results may be obscured by a variety of potential confounding factors. Future research could include additional food reward tasks in comparisons, measure covariates that may moderate the variables' associations, and compare hunger-dependent changes in food reward in different subgroups.

Dataset Information

Intravascular food reward.

Publications

Intravascular food reward.

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