Ontology highlight
ABSTRACT:
SUBMITTER: Denninger K
PROVIDER: S-EPMC3181375 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Denninger Katja K Rasmussen Susanne S Larsen Jeppe Madura JM Orskov Catrine C Seier Poulsen Steen S Sørensen Poul P Christensen Jan Pravsgaard JP Illges Harald H Odum Niels N Labuda Tord T
The American journal of pathology 20110811 4
The roles of the c-Jun N-terminal kinases (JNKs) in inflammatory arthritis have been investigated; however, the roles of each isotype (ie, JNK1 and JNK2) in rheumatoid arthritis and conclusions about whether inhibition of one or both is necessary for amelioration of disease are unclear. By using JNK1- or JNK2-deficient mice in the collagen-induced arthritis and the KRN T-cell receptor transgenic mouse on C57BL/6 nonobese diabetic (K/BxN) serum transfer arthritis models, we demonstrate that JNK1 ...[more]