On the role of corticotropin-releasing hormone receptors in anxiety and depression.
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ABSTRACT:
SUBMITTER: Reul JM
PROVIDER: S-EPMC3181666 | biostudies-literature | 2002 Mar
REPOSITORIES: biostudies-literature
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On the role of corticotropin-releasing hormone receptors in anxiety and depression.
Reul Johannes M H M JM Holsboer Florian F
Dialogues in clinical neuroscience 20020301 1
On the basis of extensive basic and clinical studies, corticotropin-releasing hormone (CRH) and its related family members are considered to play a pivotal role in stress-related disorders, such as anxiety and depression. CRH is regarded as the principal mediator in the brain of the stress response, as it mediates neuroendocrine, autonomic, and behavioral responses to stressful challenges. Recently, this neuropeptide family has expanded due to the discovery of two new members, urocortin II (also ...[more]
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