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Suzuki-Miyaura Cross-Coupling of Benzylic Bromides Under Microwave Conditions.

ABSTRACT: A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized.

SUBMITTER: McDaniel SW

PROVIDER: S-EPMC3182109 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Suzuki-Miyaura Cross-Coupling of Benzylic Bromides Under Microwave Conditions.

McDaniel Steven W SW Keyari Charles M CM Rider Kevin C KC Natale Nicholas R NR Diaz Philippe P

Tetrahedron letters 20111001 43

A procedure for benzylic Suzuki-Miyaura cross-coupling under microwave conditions has been developed. These conditions allowed for heterocyclic compounds to be coupled. Optimum conditions found were Pd(OAc)(2), JohnPhos as the catalyst and ligand, potassium carbonate as base, and DMF as the solvent. Using these conditions, a library of structurally diverse compounds was synthesized. ...[more]

PMID: 21966033

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