Kv7 channels can function without constitutive calmodulin tethering.
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ABSTRACT:
SUBMITTER: Gomez-Posada JC
PROVIDER: S-EPMC3182250 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Kv7 channels can function without constitutive calmodulin tethering.
Gómez-Posada Juan Camilo JC Aivar Paloma P Alberdi Araitz A Alaimo Alessandro A Etxeberría Ainhoa A Fernández-Orth Juncal J Zamalloa Teresa T Roura-Ferrer Meritxell M Villace Patricia P Areso Pilar P Casis Oscar O Villarroel Alvaro A
PloS one 20110928 9
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding cause Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited human epilepsy. On the basis that Kv7.2 mutants deficient in calmodulin binding are not functional, calmodulin has been defined as an auxiliary subunit of Kv7 channels. Howeve ...[more]
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