Ontology highlight
ABSTRACT:
SUBMITTER: Whitehead KA
PROVIDER: S-EPMC3182356 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Whitehead Kathryn A KA Sahay Gaurav G Li George Z GZ Love Kevin T KT Alabi Christopher A CA Ma Minglin M Zurenko Christopher C Querbes William W Langer Robert S RS Anderson Daniel G DG
Molecular therapy : the journal of the American Society of Gene Therapy 20110712 9
Despite the promise of RNA interference (RNAi) therapeutics, progress toward the clinic has been slowed by the difficulty of delivering short interfering RNA (siRNA) into cellular targets within the body. Nearly all siRNA delivery vehicles developed to date employ a single cationic or ionizable material. In order to increase the material space available for development of siRNA delivery therapeutics, this study examined the possibility of using binary combinations of ionizable lipid-like materia ...[more]