Ontology highlight
ABSTRACT:
SUBMITTER: Yi CH
PROVIDER: S-EPMC3182480 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Cell 20110801 4
Previous experiments suggest a connection between the N-alpha-acetylation of proteins and sensitivity of cells to apoptotic signals. Here, we describe a biochemical assay to detect the acetylation status of proteins and demonstrate that protein N-alpha-acetylation is regulated by the availability of acetyl-CoA. Because the antiapoptotic protein Bcl-xL is known to influence mitochondrial metabolism, we reasoned that Bcl-xL may provide a link between protein N-alpha-acetylation and apoptosis. Inde ...[more]