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Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?

ABSTRACT: In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

SUBMITTER: Elemans M

PROVIDER: S-EPMC3182865 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?

Elemans Marjet M Seich Al Basatena Nafisa-Katrin NK Klatt Nichole R NR Gkekas Christos C Silvestri Guido G Asquith Becca B

PLoS computational biology 20110929 9

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpre ...[more]

PMID: 21990968

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