Ontology highlight
ABSTRACT:
SUBMITTER: Kotas ME
PROVIDER: S-EPMC3183002 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Kotas Maya E ME Lee Hui-Young HY Gillum Matthew P MP Annicelli Charles C Guigni Blas A BA Shulman Gerald I GI Medzhitov Ruslan R
PloS one 20110929 9
Invariant natural killer T cells (iNKTs) are innate-like T cells that are highly concentrated in the liver and recognize lipids presented on the MHC-like molecule CD1d. Although capable of a myriad of responses, few essential functions have been described for iNKTs. Among the many cell types of the immune system implicated in metabolic control and disease, iNKTs seem ideally poised for such a role, yet little has been done to elucidate such a possible function. We hypothesized that lipid present ...[more]