Ontology highlight
ABSTRACT:
SUBMITTER: Mercer EM
PROVIDER: S-EPMC3183365 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Immunity 20110908 3
Recent studies have documented genome-wide binding patterns of transcriptional regulators and their associated epigenetic marks in hematopoietic cell lineages. In order to determine how epigenetic marks are established and maintained during developmental progression, we have generated long-term cultures of hematopoietic progenitors by enforcing the expression of the E-protein antagonist Id2. Hematopoietic progenitors that express Id2 are multipotent and readily differentiate upon withdrawal of I ...[more]