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Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

ABSTRACT: A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 ?M, depending on the cell line tested.

SUBMITTER: Ayers S

PROVIDER: S-EPMC3183506 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

Ayers Sloan S Graf Tyler N TN Adcock Audrey F AF Kroll David J DJ Shen Qi Q Swanson Steven M SM Wani Mansukh C MC Darveaux Blaise A BA Pearce Cedric J CJ Oberlies Nicholas H NH

Tetrahedron letters 20111001 40

A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC(50) value of 1 was moderate, ranging from 3 to 13 μM, depending on the cell line tested. ...[more]

PMID: 22025810

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