Ontology highlight
ABSTRACT:
SUBMITTER: Kim T
PROVIDER: S-EPMC3183755 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Kim Taeyoon T Hwang Wonmuk W Kamm Roger D RD
Biophysical journal 20111001 7
We develop a computational model to compare the relative importance of unbinding and unfolding of actin cross-linking proteins (ACPs) in the dynamic properties of the actin cytoskeleton. We show that in the strain-stiffening regime with typical physiological and experimental strain rates, unbinding events are predominant with negligible unfolding. ACPs unbound by greater forces experience larger displacements, with a tendency to rebind to different filaments. At constant strain, stress relaxes t ...[more]