Rapid action of estradiol in primate GnRH neurons: the role of estrogen receptor alpha and estrogen receptor beta.
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ABSTRACT:
SUBMITTER: Kenealy BP
PROVIDER: S-EPMC3183999 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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Rapid action of estradiol in primate GnRH neurons: the role of estrogen receptor alpha and estrogen receptor beta.
Kenealy B P BP Keen K L KL Terasawa E E
Steroids 20110225 9
Estrogens play a pivotal role in the control of female reproductive function. Recent studies using primate GnRH neurons derived from embryonic nasal placode indicate that 17β-estradiol (E(2)) causes a rapid stimulatory action. E(2) (1nM) stimulates firing activity and intracellular calcium ([Ca(2+)](i)) oscillations of primate GnRH neurons within a few min. E(2) also stimulates GnRH release within 10min. However, the classical estrogen receptors, ERα and ERβ, do not appear to play a role in E(2) ...[more]
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2023-10-05 | MSV000093047 | MassIVE