Dataset Information

Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness.

ABSTRACT:

Background

Ovarian cysts are a common cause for gynecological surgery. However, some cysts are a direct result of endocrine disorders and do not require surgery. This report describes an unusual case in which persistent ovarian cysts are associated with primary hypothyroidism in a young woman. The data were collected by history-taking, physical examination, laboratory tests, ultrasound, magnetic resonance imaging and a histo-pathological study. In addition, the exons of the gene encoding the human follicle-stimulating hormone receptor were sequenced.

Discussion

The patient had markedly elevated levels of thyroid-stimulating hormone and follicle-stimulating hormone and an enlarged pituitary gland. After treatment with thyroid hormone replacement, regression of the enlarged pituitary and the ovarian cysts was observed. The possible mechanisms of the pathophysiology are discussed below.

Summary

It is necessary to consider hypothyroidism and other endocrine disorders in the differential diagnosis of adult patients with ovarian multiple cyst formation in order to prevent inadvertent ovarian surgery.

SUBMITTER: Shu J

PROVIDER: S-EPMC3184057 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness.

Shu Jing J Xing Lili L Zhang Lingyan L Fang Suhua S Huang Hefeng H

Reproductive biology and endocrinology : RB&E 20110823

<h4>Background</h4>Ovarian cysts are a common cause for gynecological surgery. However, some cysts are a direct result of endocrine disorders and do not require surgery. This report describes an unusual case in which persistent ovarian cysts are associated with primary hypothyroidism in a young woman. The data were collected by history-taking, physical examination, laboratory tests, ultrasound, magnetic resonance imaging and a histo-pathological study. In addition, the exons of the gene encoding ...[more]

PMID: 21861901

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Project description:Introduction Adolescents and young adults are a vulnerable patient population for development of substance use disorder. However, the long-term impact of opioid prescribing in young adult patients with renal colic is not known. Our objective was to describe rates of opioid prescription and identify risk factors for persistent opioid use in patients age 25 years or younger with renal colic from kidney stones. Methods Using previously validated, linked administrative databases, we performed a population-based, retrospective cohort study of opioid-naive patients age 25 years or younger with renal colic between July 1, 2013 and September 30, 2017 in Ontario. All family practitioner, urgent care, and specialist visits in the province were captured. Our primary outcome was persistent opioid use, defined as filling a prescription for an opioid between 91 and 180 days after initial visit. Ontario uses a narcotic monitoring system, which captures all opioids dispensed in the province. Results Of the 6962 patients identified, 56% were prescribed an opioid at presentation and 34% of those were dispensed more than 200 oral morphine equivalents. There was persistent opioid use in 313 (8.1%) patients who filled an initial opioid prescription. In adjusted analysis, those prescribed an opioid initially had a significantly higher risk of persistent opioid use (odds ratio [OR] 1.85; 95% confidence interval [CI] 1.50–2.29) and opioid overdose (OR 3.45; 1.08–11.04). There was a dose-dependent increase in risk of persistent opioid use with escalating initial opioid dose. History of mental illness (OR 1.32; 1.02–1.71) and need for surgery (OR 1.71; 1.24–2.34) were also associated with persistent opioid use. Conclusions Among patients with kidney stones age 25 years or younger, filling an opioid prescription after presentation is associated with an increased risk of persistent opioid use 3–6 months later and a higher risk of serious long-term complications, such as opioid overdose.

Dataset Information

Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness.

Background

Discussion

Summary

Publications

Ignored adult primary hypothyroidism presenting chiefly with persistent ovarian cysts: a need for increased awareness.

Similar Datasets

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