Ontology highlight
ABSTRACT:
SUBMITTER: Campbell JJ
PROVIDER: S-EPMC3184152 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Campbell Jonathan J JJ Davidenko Natalia N Caffarel Maria M MM Cameron Ruth E RE Watson Christine J CJ
PloS one 20110930 9
Studies on the stem cell niche and the efficacy of cancer therapeutics require complex multicellular structures and interactions between different cell types and extracellular matrix (ECM) in three dimensional (3D) space. We have engineered a 3D in vitro model of mammary gland that encompasses a defined, porous collagen/hyaluronic acid (HA) scaffold forming a physiologically relevant foundation for epithelial and adipocyte co-culture. Polarized ductal and acinar structures form within this scaff ...[more]