Ontology highlight
ABSTRACT:
SUBMITTER: Pan E
PROVIDER: S-EPMC3184234 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Pan Enhui E Zhang Xiao-an XA Huang Zhen Z Krezel Artur A Zhao Min M Tinberg Christine E CE Lippard Stephen J SJ McNamara James O JO
Neuron 20110921 6
The presence of zinc in glutamatergic synaptic vesicles of excitatory neurons of mammalian cerebral cortex suggests that zinc might regulate plasticity of synapses formed by these neurons. Long-term potentiation (LTP) is a form of synaptic plasticity that may underlie learning and memory. We tested the hypothesis that zinc within vesicles of mossy fibers (mf) contributes to mf-LTP, a classical form of presynaptic LTP. We synthesized an extracellular zinc chelator with selectivity and kinetic pro ...[more]