Dataset Information

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

ABSTRACT:

Background

The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.

Methods

We conducted a case-control study with 105 patients with suicide attempts and 236 controls. Subsequently, we performed a meta-analysis of published genetic association studies by searching through Medline, PubMed and Web of Science databases.

Results

No significant differences were found in the distribution of alleles (?2 = 0.33, 1 df, p = 0.56) or genotypes (?2 = 2.36, 2 df, p = 0.26). The meta-analysis comprising 12 association studies (including the present one) showed that the risk COMTmet allele of COMTval158/met is not associated with suicidal behavior (OR: 1.09, 95% CI: 0.97-1.23), even in the absence of heterogeneity (OR: 1.09, 95% CI: 0.97-1.23).

Conclusion

Our results showed no association between COMTval158/met and suicidal behavior. However, more studies are necessary to determine conclusively an association between COMT and suicidal behavior.

SUBMITTER: Tovilla-Zarate C

PROVIDER: S-EPMC3184265 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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Publications

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

Tovilla-Zárate Carlos C Juárez-Rojop Isela I Ramón-Frias Teresa T Villar-Soto Mario M Pool-García Sherezada S Medellín Beatriz Camarena BC Genis Mendoza Alma D AD Narvaez Lilia López LL Humberto Nicolini N

BMC psychiatry 20110921

<h4>Background</h4>The polymorphism COMTval158met has been associated with suicidal behavior in case-control and meta-analysis studies, but results and conclusions remain controversial. The objective of this study was to examine the association between COMT val158met with suicidal behavior in a case-control study and to assess the combined evidence -this case-control study and available data from other related studies- we carried out a meta-analysis.<h4>Methods</h4>We conducted a case-control st ...[more]

PMID: 21936936

Similar Datasets

Project description:Neither environmental nor genetic factors are sufficient to predict the transdiagnostic expression of psychosis. Therefore, analysis of gene-environment interactions may be productive.A meta-analysis was performed using papers investigating the interaction between cannabis use and catechol-O-methyl transferase (COMT) polymorphism Val158Met (COMTVal158Met).PubMed, Embase, PsychInfo.All observational studies assessing the interaction between COMTVal158Met and cannabis with any psychosis or psychotic symptoms measure as an outcome.A meta-analysis was performed using the Meta-analysis of Observational Studies in Epidemiology guidelines and forest plots were generated. Thirteen articles met the selection criteria: 7 clinical studies using a case-only design, 3 clinical studies with a dichotomous outcome, and 3 studies analysing a continuous outcome of psychotic symptoms below the threshold of psychotic disorder. The three study types were analysed separately. Validity of the included studies was assessed using "A Cochrane Risk of Bias Assessment Tool: for Non-Randomized Studies of Interventions".For case-only studies, a significant interaction was found between cannabis use and COMTVal158Met, with an OR of 1.45 (95% Confidence Interval = 1.05-2.00; Met/Met as the risk genotype). However, there was no evidence for interaction in either the studies including dichotomous outcomes (B = -0.51, 95% Confidence Interval -1.72, 0.70) or the studies including continuous outcomes (B = -0.04 95% Confidence Interval -0.16-0.08).A substantial part of the included studies used the case-only design, which has lower validity and tends to overestimate true effects.The interaction term between cannabis use and COMTVal158Met was only statistically significant in the case-only studies, but not in studies using other clinical or non-clinical psychosis outcomes. Future additional high quality studies might change current perspectives, yet currently evidence for the interaction remains unconvincing.

Dataset Information

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

Background

Methods

Results

Conclusion

Publications

No association between COMT val158met polymorphism and suicidal behavior: meta-analysis and new data.

Similar Datasets

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