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Cross-coupling of mesylated phenol derivatives with potassium cyclopropyltrifluoroborate.

ABSTRACT: C-O activation of mesylates by a palladium catalyst and subsequent cross-coupling with potassium cyclopropyltrifluoroborate have been achieved with high yield. Both electron-enriched and electron-deficient aryl mesylates are suitable electrophilic partners for the Suzuki-Miyaura reaction. The scope was successfully extended to heteroaryl mesylates with yields up to 94%.

SUBMITTER: Molander GA

PROVIDER: S-EPMC3184376 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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Cross-coupling of mesylated phenol derivatives with potassium cyclopropyltrifluoroborate.

Molander Gary A GA Beaumard Floriane F Niethamer Terren K TK

The Journal of organic chemistry 20110902 19

C-O activation of mesylates by a palladium catalyst and subsequent cross-coupling with potassium cyclopropyltrifluoroborate have been achieved with high yield. Both electron-enriched and electron-deficient aryl mesylates are suitable electrophilic partners for the Suzuki-Miyaura reaction. The scope was successfully extended to heteroaryl mesylates with yields up to 94%. ...[more]

PMID: 21888362

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