Ontology highlight
ABSTRACT:
SUBMITTER: Charvet C
PROVIDER: S-EPMC3184637 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Charvet Céline C Wissler Manuela M Brauns-Schubert Prisca P Wang Shang-Jui SJ Tang Yi Y Sigloch Florian C FC Mellert Hestia H Brandenburg Martin M Lindner Silke E SE Breit Bernhard B Green Douglas R DR McMahon Steven B SB Borner Christoph C Gu Wei W Maurer Ulrich U
Molecular cell 20110601 5
Activation of p53 by DNA damage results in either cell-cycle arrest, allowing DNA repair and cell survival, or induction of apoptosis. As these opposite outcomes are both mediated by p53 stabilization, additional mechanisms to determine this decision must exist. Here, we show that glycogen synthase kinase-3 (GSK-3) is required for the p53-mediated induction of the proapoptotic BH3 only-protein PUMA, an essential mediator of p53-induced apoptosis. Inhibition of GSK-3 protected from cell death ind ...[more]