Ontology highlight
ABSTRACT:
SUBMITTER: Read ML
PROVIDER: S-EPMC3184940 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Read Martin L ML Lewy Greg D GD Fong Jim C W JC Sharma Neil N Seed Robert I RI Smith Vicki E VE Gentilin Erica E Warfield Adrian A Eggo Margaret C MC Knauf Jeffrey A JA Leadbeater Wendy E WE Watkinson John C JC Franklyn Jayne A JA Boelaert Kristien K McCabe Christopher J CJ
Cancer research 20110815 19
Pituitary tumor transforming gene (PTTG)-binding factor (PBF or PTTG1IP) is a little characterized proto-oncogene that has been implicated in the etiology of breast and thyroid tumors. In this study, we created a murine transgenic model to target PBF expression to the thyroid gland (PBF-Tg mice) and found that these mice exhibited normal thyroid function, but a striking enlargement of the thyroid gland associated with hyperplastic and macrofollicular lesions. Expression of the sodium iodide symp ...[more]