Ontology highlight
ABSTRACT:
SUBMITTER: Vendrell A
PROVIDER: S-EPMC3185340 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Vendrell Alexandre A Martínez-Pastor Mar M González-Novo Alberto A Pascual-Ahuir Amparo A Sinclair David A DA Proft Markus M Posas Francesc F
EMBO reports 20110930 10
Exposure of yeast to high osmolarity induces a transient activation of the Hog1 stress-activated protein kinase (SAPK), which is required for cell survival under these conditions. However, sustained activation of the SAPK results in a severe growth defect. We found that prolonged SAPK activation leads to cell death, which is not observed in nma111 cells, by causing accumulation of reactive oxygen species (ROS). Mutations of the SCF(CDC4) ubiquitin ligase complex suppress cell death by preventing ...[more]