Ontology highlight
ABSTRACT:
SUBMITTER: Hackmann A
PROVIDER: S-EPMC3185341 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Hackmann Alexandra A Gross Thomas T Baierlein Claudia C Krebber Heike H
EMBO reports 20110930 10
The nuclear export of large ribonucleoparticles is complex and requires specific transport factors. Messenger RNAs are exported through the RNA-binding protein Npl3 and the interacting export receptor Mex67. Export of large ribosomal subunits also requires Mex67; however, in this case, Mex67 binds directly to the 5S ribosomal RNA (rRNA) and does not require the Npl3 adaptor. Here, we have discovered a new function of Npl3 in mediating the export of pre-60S ribosomal subunit independently of Mex6 ...[more]