Ontology highlight
ABSTRACT:
SUBMITTER: Wu B
PROVIDER: S-EPMC3185412 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Wu Bin B Davey Gabriela E GE Nazarov Alexey A AA Dyson Paul J PJ Davey Curt A CA
Nucleic acids research 20110630 18
Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic activity. By crystallographic analysis of transition metal-and in particular platinum compound-DNA site selectivity in the nucleosome core, we establish that steric accessibility, which is controlled by specific structural parameters of the double ...[more]