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ABSTRACT:
SUBMITTER: Muhlbach H
PROVIDER: S-EPMC3185506 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Mühlbach Hermine H Mohr Christian A CA Ruzsics Zsolt Z Koszinowski Ulrich H UH
Viruses 20091019 3
Investigating and assigning gene functions of herpesviruses is a process, which profits from consistent technical innovation. Cloning of bacterial artificial chromosomes encoding herpesvirus genomes permits nearly unlimited possibilities in the construction of genetically modified viruses. Targeted or randomized screening approaches allow rapid identification of essential viral proteins. Nevertheless, mapping of essential genes reveals only limited insight into function. The usage of dominant-ne ...[more]