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ABSTRACT: Background and objectives
Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41% prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurements of LVM were performed using cardiac magnetic resonance (MR).Design, setting, participants, & measurements
Five hundred forty-three hypertensive patients with GFR >60 ml/min per 1.73 m(2) underwent MR assessment of LVM at baseline. LVM was adjusted for body surface area and expressed as LVM index (LVMI; g/m(2)).Results
Baseline BP was 125.1 ± 14.5/79.3 ± 11.6 mmHg. Average duration of hypertension was 5.79 years. Prior use of angiotensin-converting enzyme inhibitors or angiotensin receptor blockers was present in 59.5% of patients. The prevalence of LVH assessed using nonindexed LVM (g) was 3.9% (n = 21, eight men and 13 women) and 0.93% (n = 5, one man and four women) using LVMI (g/m(2)). In exploratory analyses, the prevalence of LVH using LVM indexed to H(2.7), and the allometric index ppLVmass(HW), ranged from 0.74% to 2.23% (n = 4 to 12). Multivariate regression showed significant direct associations of LVMI with systolic BP, serum creatinine, and albuminuria; significant inverse associations with LVMI were found with age and female gender.Conclusions
The prevalence of LVH in hypertensive ADPKD patients <50 years of age with short duration of hypertension, and prior use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers is low. Early BP intervention in ADPKD may have decreased LVH and may potentially decrease cardiovascular mortality.
SUBMITTER: Perrone RD
PROVIDER: S-EPMC3186455 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Perrone Ronald D RD Abebe Kaleab Z KZ Schrier Robert W RW Chapman Arlene B AB Torres Vicente E VE Bost James J Kaya Diana D Miskulin Dana C DC Steinman Theodore I TI Braun William W Winklhofer Franz T FT Hogan Marie C MC Rahbari-Oskoui Frederic F Kelleher Cass C Masoumi Amirali A Glockner James J Halin Neil J NJ Martin Diego D Remer Erick E Patel Nayana N Pedrosa Ivan I Wetzel Louis H LH Thompson Paul A PA Miller J Philip JP Bae K Ty KT Meyers Catherine M CM
Clinical journal of the American Society of Nephrology : CJASN 20110908 10
<h4>Background and objectives</h4>Autosomal dominant polycystic kidney disease (ADPKD) is associated with a substantial cardiovascular disease burden including early onset hypertension, intracranial aneurysms, and left ventricular hypertrophy (LVH). A 41% prevalence of LVH has been reported in ADPKD, using echocardiographic assessment of LV mass (LVM). The HALT PKD study was designed to assess the effect of intensive angiotensin blockade on progression of total kidney volume and LVM. Measurement ...[more]