Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.
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ABSTRACT:
SUBMITTER: Chauvier D
PROVIDER: S-EPMC3186905 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
Targeting neonatal ischemic brain injury with a pentapeptide-based irreversible caspase inhibitor.
Chauvier D D Renolleau S S Holifanjaniaina S S Ankri S S Bezault M M Schwendimann L L Rousset C C Casimir R R Hoebeke J J Smirnova M M Debret G G Trichet A-P AP Carlsson Y Y Wang X X Bernard E E Hébert M M Rauzier J-M JM Matecki S S Lacampagne A A Rustin P P Mariani J J Hagberg H H Gressens P P Charriaut-Marlangue C C Jacotot E E
Cell death & disease 20110901
Brain protection of the newborn remains a challenging priority and represents a totally unmet medical need. Pharmacological inhibition of caspases appears as a promising strategy for neuroprotection. In a translational perspective, we have developed a pentapeptide-based group II caspase inhibitor, TRP601/ORPHA133563, which reaches the brain, and inhibits caspases activation, mitochondrial release of cytochrome c, and apoptosis in vivo. Single administration of TRP601 protects newborn rodent brai ...[more]
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