Ontology highlight
ABSTRACT:
SUBMITTER: Ying H
PROVIDER: S-EPMC3186945 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Cancer discovery 20110523 2
Initiation of pancreatic ductal adenocarcinoma (PDAC) is driven by oncogenic KRAS mutation, and disease progression is associated with frequent loss of tumor suppressors. In this study, human PDAC genome analyses revealed frequent deletion of the PTEN gene as well as loss of expression in primary tumor specimens. A potential role for PTEN as a haploinsufficient tumor suppressor is further supported by mouse genetic studies. The mouse PDAC driven by oncogenic Kras mutation and Pten deficiency als ...[more]