Unknown

Dataset Information

0

First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.


ABSTRACT: Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.

SUBMITTER: Bador J 

PROVIDER: S-EPMC3186983 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.

Bador Julien J   Amoureux Lucie L   Duez Jean-Marie JM   Drabowicz Anthony A   Siebor Eliane E   Llanes Catherine C   Neuwirth Catherine C  

Antimicrobial agents and chemotherapy 20110801 10


Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol. ...[more]

Similar Datasets

| S-EPMC3535963 | biostudies-literature
| S-EPMC2423046 | biostudies-literature
| S-EPMC3122131 | biostudies-literature
| S-EPMC8749003 | biostudies-literature
| S-EPMC2696896 | biostudies-literature
2021-04-30 | GSE169036 | GEO
| S-EPMC4754349 | biostudies-literature
| S-EPMC7331594 | biostudies-literature
| S-EPMC6471707 | biostudies-literature
| S-EPMC5961088 | biostudies-literature