Ontology highlight
ABSTRACT:
SUBMITTER: Bador J
PROVIDER: S-EPMC3186983 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Bador Julien J Amoureux Lucie L Duez Jean-Marie JM Drabowicz Anthony A Siebor Eliane E Llanes Catherine C Neuwirth Catherine C
Antimicrobial agents and chemotherapy 20110801 10
Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol. ...[more]