Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.
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ABSTRACT:
SUBMITTER: Desai C
PROVIDER: S-EPMC3187061 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
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Candida albicans SRR1, a putative two-component response regulator gene, is required for stress adaptation, morphogenesis, and virulence.
Desai Chirayu C Mavrianos John J Chauhan Neeraj N
Eukaryotic cell 20110812 10
We report here the identification and characterization of a previously uncharacterized, two-component response regulator gene (orf19.5843) from Candida albicans. Because of its apparent functions in stress adaptation, we have named this gene SRR1 (stress response regulator 1). Disruption of SRR1 causes defects in hyphal development, reduced resistance to stress, and severe virulence attenuation in the mouse model of disseminated candidiasis. ...[more]
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